Posts Tagged ‘Depression Prevention’

AVOID DEPRESSION BY SEEING OTHERS MORE POSITIVELY

Sunday, September 5th, 2010

In AA they have a saying which goes, “When you point a finger at someone else you’re pointing three back at yourself.” The saying is meant to expose hypocrisy (faulting another for what you’re guilty of); and also to help AA members have more tolerance for and acceptance of others. Dustin Wood, Ph.D., assistant professor psychology at Wake Forest University, has just published a valuable study on the mental health aspects of what we say about other people in the July 2010 issue the Journal of Personality and Social Psychology.

Dr. Wood recruited a group of people to learn the psychological implications of what people say about each others. He had friends rate each other, college freshmen rate others they knew in their dorms, and fraternity and sorority members rate others in their organization. He then had the raters undergo psychological and personality testing.

There were two key findings. First there is a strong association between positively judging others and how enthusiastic, happy, kind-hearted, courteous, emotionally stable and capable the person describes oneself and is described by others. Second negative perceptions of others are associated with higher levels of narcissism, other personality disorders and anti-social behavior. Dr. Wood said “The simple tendency to see people negatively indicates a greater likelihood of depression….”

Dr. Wood’s research showed that the greater the negativity in your assessment of others the more likely you are unhappy, disagreeable and neurotic. Could there be a link between the incivility epidemic in contemporary legal practice and the fact that 1 out of every 5 lawyers suffers from major depression? Since we live in the world our mind creates the answer is likely to be yes. If you have bad things to say about most of your colleagues and you are unhappy most of the time, then you should start thinking very seriously about making a change.

Today is a new day. Begin with a practice of finding good things to say about others at the office. It won’t come easy at first, but will get easier with practice. The more positive things you say about others, the more positive things you will see in them, appreciate and take pleasure in. The people around you will notice the change and start feeling a whole lot more positive about you. Over time the veil of misery will lift. Once you’ve proven to yourself that this technique works, you can recommend it to other lawyers. Pass it on.

CHRONIC ALCOHOL DEPENDENT DRINKING DISRUPTS CIRCADIAN RHYTHMS CAUSING INSOMNIA AND DEPRESSION

Thursday, August 26th, 2010

Human beings have a 24 hour biological rhythm cued by changes in daylight called a circadian rhythm. The mammalian clock that regulates our sleep-wake cycle lies in the suprachiasmatic nucleus of the hypothalamus. Temporary disruption of circadian rhythm by international flights causes a combination of insomnia and fatigue known as jet lag.

Every 24 hours we not only show changes in wakefulness, but also in body temperature, hormone production, brain waves and feeding behavior. Many tissues in our body have circadian clock genes. These genes must be expressed properly in the form of transcription and clock proteins for us to survive. Their appropriate expression is a key for people to sleep well, stay healthy and maintain a good mood. In order to operate properly these genes must have sufficient messenger RNA (ribonucleic acid) to manufacture certain proteins.

It has long been known that people who drink heavily on a chronic basis have problems with insomnia and depression. Researchers Ming-Chyi Huang and collaborators at Taipei Medical University and Taipei City Hospital wanted to know if this was related to depletion of messenger RNA in their circadian clock genes.

The researchers recruited 22 male patients diagnosed with alcohol dependency and 12 healthy control subjects. Study of their blood samples showed markedly lower baseline levels of messenger RNA in the circadian clock genes of the AD patients. The study also showed destruction of normal circadian clock gene expression in the AD patients. Reduced circadian clock expression did not normalize following early alcohol withdrawal treatment. Researcher Sy-Jye Leu said this shows that chronic AD has long term damaging effects on the expression of circadian rhythm genes. Their finds were communicated early on 8/24/10, but will be published in full in the November 2010 issue of Alcoholism: Clinical & Experimental Research.

For alcoholic lawyers in denial it’s important to realize that continuing to drink is tampering with your very genes and altering the basic circadian rhythm that sets the time for normal, healthy changes in sleep, waking, brain waves, hormone production, body temperature and hunger. Research from Dr. Joseph Takahashi of the Howard Hughes Medical Institute came out on July 13, 2010, indicating that chronic disruption of circadian rhythm can cause diabetes by impairing the ability of the pancreas to release insulin.

If you’re a lawyer with an alcohol problem who is still in denial, then it’s high time you sought treatment.

HOW TO DEFEAT FOOD CRAVINGS THAT CAUSE DEPRESSION

Thursday, August 12th, 2010

The rate of depression in American society today is approximately 10 times what it was during World War II. There are many different explanations for this, but it is generally agreed that the rise in depression reflects changes in life style. One change in life style which has contributed to this increase in the rate of depression is what we eat. Changes in our eating patterns have caused soaring rates of obesity, heart disease, stroke and depression. During WWII people were much more likely to engage in daily consumption of whole foods (fruits, vegetables and whole grains) than they are today. We are now living in a time when 70% of the food supply is made of processed and refined foods stripped of all virtually nutrients.

As one expert put it we are starving not because of food scarcity but because we don’t choose wisely from the abundance of available food. When it comes to mental health food can be medicine or poison. Whole foods and Omega 3 fish oil supplements support our mental health, while regular consumption of foods which are high in refined sugar, deep fried or high in partially hydrogenated fats lead to depression and dementia.

There are reasons why we’ve stopped eating healthy foods and why we eat so much of the foods that cause depression. Part of it is our hyper-busy life style. We put so much time into work and commuting that we don’t want to take the time to buy raw ingredients, find a recipe and spend 20 minutes preparing a home meal. We just want fast, pre-made convenience foods. Part of it is marketing. TV and magazines show people like us eating high fat, high sugar and deep fried foods (like deep fried Snickers, Twinkies or ice cream) with unbridled joy. When we walk into a grocery store the displays for fattening cakes, pies, cookies, and ice creams, are like works of art that reach through our eyes into our bellies and then ring an alarm in our brain that says “Gotta have it!”

Approximately 90% of human intelligence is subcortical which means it operates spontaneously beneath the level of consciousness. Brain research shows that most of our motivation to act is unconscious and that we respond to cues without conscious awareness. Mathias Pessiglione and colleagues at the Brain & Spine Institute in Paris have done some classic experiments which make this point. In one of them the participants were asked to squeeze a handgrip harder to get one coin rather than another. They kept squeezing the handgrip harder for the one Euro coin than for the one cent coin even though the images were flashed on a screen much too quickly for the conscious mind to register and could only be detected subliminally.

The one Euro and the one cent coins are simply pieces of metal. Society makes one more desirable than another by placing a differential value on them. We live in a society that has been putting way more value on unhealthy fast food than healthy, slow food, and it is only through conscious choice that we can reverse it for ourselves. We have to start thinking about the long time consequences of each small choice, because our small choices have an enormous cumulative effect on our health.

The same runs true for our crazy busy lives. One way is to keep racing from appointment to appointment while texting or cell phoning each other en route.  The other is to choose to slow down and block out some time for buying and preparing whole foods to make a delicious, healthy meal. One expert has called home chores (which include meal preparation) Prehistoric Prozac, because creating something of value to our survival with our hands was wired into the brains of our ancestors as a source of pride and pleasure.

All of this sounds good but what about the fact that you when see the tubs of glistening ice cream bursting with chocolate chunks and nuts or the perfect cakes with the most gorgeous, lip-smacking icing you have an irresistible impulse to buy some and devour it?

Brain research has gotten to the point where we know why and how this happens and what we can do about it. In late June 2010 Professor Ray Dolan and his colleague Dr. Pine at the Wellcome Trust Centre for Neuroimaging at University College London published their research on dopamine and impulsivity in the Journal of Neuroscience. Dopamine is a neurotransmitter that plays a key role in reward, motivation, learning through reinforcement and addiction. People with mania and ADHD are known to act very impulsively and they have high levels of dopamine. People with Parkinson’s have great difficulty initiating basic actions like walking and talking because they have low dopamine levels.

Dr. Dolan wanted to see how extra dopamine would affect the decision making of ordinary people – would it make them opt for instant gratification rather than wait for a more beneficial reward in the future. In the experiment he recruited 14 healthy volunteers under two conditions: once when given a small (150mg) dose of L-dopa which increases the level of brain dopamine, and once when given a placebo. Under each condition, the subjects were asked to make a number of choices consisting of either a ’smaller, sooner’ option, for example receiving £15 in two weeks, or a ‘larger, later’ option, such as receiving £57 in six months.

The researchers found that every subject was more likely to behave more impulsively — choosing the ’smaller, sooner’ option — when levels of dopamine in the brain were boosted. Dr Pine believes that this finding may also explain why we tend to behave more impulsively when influenced by external ‘cues’. “We know that sensory inputs — sights, sounds smells and anticipation of rewards, or even of neutral cues which have been associated with rewards — momentarily boost dopamine levels in our brains, and our research shows that higher dopamine levels make us act more impulsively,” he says.

Although we all want to be healthy and avoid obesity, diabetes, heart disease and depression, isn’t it hopeless since we need willpower and willpower is exactly what dissolves the moment we see warm apple pie a la mode or chocolate mousse cake topped with whipped cream and dark chocolate espresso bean? Willpower is a mental construct of the conscious mind like the self. No brain scanner has ever found an area of the brain that could be said to be the seat of human volition.

We are, as Aristotle said, creatures of the habits we create by our actions. Our actions can create momentum in favor of or against healthy food choices. Knowing a bit of neuroscience is hugely helpful, because it enables us to appreciate that when we get a sudden compulsion to eat something unhealthy we are experiencing a craving that has been ignited by a temporary spike in dopamine. We also know that such cravings are most likely to arise when we are stressed out, because stress depletes serotonin (the brain’s feel good chemical) and increases cortisol (a stress hormone which makes us feel bad). What is crucial here is that we aren’t puppets. We don’t have to treat the craving as a command from control center which we must obey.

The most effective way to defeat such cravings is to switch mental gears so you can release the tension in your body and reconnect with your rational concern for your long term health. There are at least three different to do this that I’m aware of. Dr. A. Thomas Horvath (author of Sex, Drugs, Gambling & Chocolate) says that cravings involve the feeling “I must have x or I will die,” but cravings never killed anyone. He says that if you wait long enough (which is rarely more than a minute or so) your mind will jump to another subject and the craving will be forgotten. How long, he asks, can you keep thinking of a pink cow?

Another approach comes from Les Fehmi, Ph.D., (author of The Open-Focus Brain). Dr. Fehmi says we become most tense and anxious when our attention narrows to one object in the foreground of our consciousness and we push all other objects to the distant background. The way to relax and release bodily tension is to open up your attentional field to take in yourself, your internal sensations and feelings, all the objects around you, and the space between objects. It’s like opening the aperture of a camera from the narrowest to the widest. This opening of mental focus instantly relaxes the mind and body.

The third approach comes from Buddhist meditation. Buddhist meditators achieve a state of peace, calm, and equanimity, by practicing the art of allowing mental content (ideas, images, feelings and yes, cravings) to arise, pass and disappear. They neither struggle to push them away or grasp them tightly. They simply allow them to come and go like clouds on the screen of their consciousness which they call awareness. If you practice meditation daily you become skilled at the art of non-attachment and this makes it much easier to tolerate transient cravings. Some meditators turn in a spirit of openness and curiosity towards the mental content which troubles them, which could be fear, pain or a craving of some kind. They explore this mental content from inside and they find that the very process of exploring it makes it disappear.

Undoubtedly there are other mental approaches to defeating cravings for unhealthy foods, but whatever they are, I assume they share one common denominator. What is common to the three approaches I have recommended is a mindful catching of  yourself in the act of becoming immensely attracted to a bit of unhealthy food, of acknowledging the craving and making space for it in your consciousness so it diffuses.

This is far preferable to mindlessly just giving in or consciously resisting in an extremely effortful way involving fight-flight with release of stress hormones. The all-or-nothing approach to a fudge cake doesn’t work – either gluttonously gobbling up half a cake after a week of dieting and feeling shame/guilt or having a momentous and highly emotional internal debate as if Congress were debating whether to go to war. Those sorts of debates leave you lightheaded with shallow breathing, clenched muscles and an uncomfortable tingling in your limbs. Restaurants and grocery stores will always arouse cravings in us because the people who run them design them to do just that, but they aren’t battlefields. If you experience a craving you can diffuse it by waiting it out, opening up your attentional field, allowing it to pass like a cloud or by exploring it with curiosity.

IT’S EASIER THAN YOU THINK TO MAKE A POSITIVE DIFFERENCE IN THE LIVES OF OTHERS YOU CARE ABOUT

Saturday, August 7th, 2010

The following is the philosophy of Charles Schulz, the creator of the ‘Peanuts’ comic strip. You don’t have to actually answer the questions. Just ponder on them.

1. Name the five wealthiest people in the world.
2. Name the last five Heisman trophy winners.
3. Name the last five winners of the Miss America pageant.
4. Name ten people who have won the Nobel or Pulitzer Prize.
5. Name the last half dozen Academy Award winners for best actor and  actress.
6. Name the last decade’s worth of World Series Winners.

How did you do? 
The point is, none of us remember the headliners of yesterday.
These are no second-rate achievers.
They are the best in their fields.
But the applause dies..
Awards tarnish..
Achievements are forgotten.
Accolades and certificates are buried with their owners.

Here’s another quiz.. See how you do on this one: 

1. List a few teachers who aided your journey through school.
2. Name three friends who have helped you through a difficult time.
3. Name five people who have taught you something worthwhile.
4. Think of a few people who have made you feel appreciated and special!!
5. Think of five people you enjoy spending time with.

Easier? 

The lesson:
The people who make a difference in your life are not the ones with the most credentials..
the most money…or the most awards.
They simply are the ones who care the most 

If you think you have to be a Superlawyer earning seven figures a year to earn the respect and affection of your family, friends, and colleagues, you may be leading yourself by nose into depression. Charles Schultz shows us the folly of that line of thinking. If you take the time to listen, to show sincere interest, to be supportive and to act with kindness, then you will have real friends and a good, happy life and career, and you will avoid rather invite depression.

STATINS PROTECT YOUR HEART BUT MAY CONTRIBUTE TO DEPRESSION AND DEMENTIA

Monday, June 28th, 2010
The statins (drugs like Zocor, Mevacor and Lipitor) are the most heavily prescribed cholesterol lowering drugs on earth. They bring in 25 billion dollars annually from worldwide sales. The theory for prescribing them is that statins reduce arterial clogging, hypertension and heart disease by reducing cholesterol (a waxy textured mixture of fats) in the blood. They do this by inhibiting the function of HMG-CoA reductase, a key enzyme responsible for the biosynthesis of cholesterol. The problem with statins is that they work too well. They tip the balance of cholesterol from too high to too low.
Although depression is the product of multiple causes, one known cause is insufficiency of serotonin in the brain, and the sole purpose of America’s best selling anti-depressant drugs (like Prozac and Zoloft) is to raise the amount of brain serotonin by blocking its re-uptake after it is secreted. Amitabha Chattopadhyay, Ph.D., of the Centre for Cellular and Molecular Biology in Hyderabad, India, has shown in the laboratory that the receptors for serotonin in brain cell membranes need a certain minimal amount of cholesterol to function and that long term use of statins impairs the function of these receptors by lowering cholesterol too much.
Dr. Chattopadhyay reported his research in the June 3, 2010 issue of Biochemistry. He placed animal cells called Chinese Hamster Ovary cells, which had been cloned to express human serotonin receptors, into a test tube. When he subjected these cells to mevastatin he observed that over time they ceased to function properly. But when he added cholesterol to the test tube the function of the serotonin receptors was restored to normal. Dr. Chattopadhyay concluded that chronically low levels of cholesterol in the brain from long term use of a statin drug could cause anxiety and depression in a heart patient.
I note that Dr. Chattopadhyay is an American trained chemist and internationally respected expert in cell membranes. The journal of Biochemistry, one of 34 peer reviewed journals put out by the American Chemical Society, was voted one of the most 100 influential journals in their fields during the last 100 years by the Special Libraries Association. This study is an important one. It suggests that taking a statin undermines the benefit of taking an SSRI anti-depressant. Having more sertonin in your brain from an SSRI won’t help if your cholesterol starved serotonin receptors aren’t working.  If you suffer from depression and your doctor has prescribed a statin or you are considering going on a statin, please talk to your doctor about this study. While protecting your heart health is an absolute necessity, you don’t want to do it in a way that causes you depression or increases the depression you already have. Your doctor may have a solution.
Regarding statins and dementia, American neurosurgeon Larry McCleary
has written in The Brain Trust Program that statins block the production of an important anti-oxidant called CQ-10 which is found in the human brain. Dietary sources of CQ-10 are liver, salmon, nuts, soy and canola oil. Lab research shows that high concentrations of CQ-10 are protective against Alzheimer’s disease, Parkinson’s disease and ALS. Dr. McCleary says that most people are deficient in CQ-10 and should take a daily CQ-10 supplement. He has expressed concern that taking a statin could expose people to increased risk of degenerative brain disease with dementia. If you are taking a statin you should discuss this with your doctor along with the idea of taking a CQ-10 supplement.
My father has been taking a statin for years, and his cholesterol levels are very good. He is quite healthy at age 85, and we are going to fly to New Jersey in mid-July 2010 to celebrate this milestone birthday with him. Clearly statins have done him good.
But my father was never prone to depression (which means he wasn’t born with a serotonin-deficiency problem) and we have no known cases of Alzheimer’s disease in our family tree, so his risk levels for depression and Alzheimer’s were quite low. The risk level for depression, dementia or both, for a person taking a statin on a long term basis would presumably be quite different for someone with a family history of these problems, or someone already suffering from depression. Such at-risk people should be concerned about increasing their risk by long term statin use.

REDUCE DEPRESSION BY BULKING UP YOUR ANTERIOR CINGULATE CORTEX WITH MEDITATION

Friday, June 4th, 2010

A cingulate is a curved bundle of nerves. The anterior cingulate cortex (ACC) is a collar shaped bundle of nerves that surrounds the corpus callosum within the frontal lobes of the human brain. The dorsal (top) portion of the ACC is involved with the cognitive function of monitoring task completion. The dorsal ACC helps us pay attention to where we are directing our attention and facilitates learning. It is stimulated by novelty and some neuroscientists believe it plays a role in error detection. The ventral (bottom) portion of the ACC has connections with many key brain areas. These are the amygdala (the brain’s fear alarm); the hypothalamus (which regulates appetite, sleep, and sex drive, and which also triggers the secretion of the stress hormones adrenalin and cortisol via the pituitary when the amygdala signals the approach of a threat); the nucleus accumbens (which uses dopamine to create the experiences of reward and pleasure); and the insula (the brain’s empathy center).

The ACC is situated between the frontal lobes (the seat of rational thought,  impulse control, self-image and self-esteem) and the subcortical limbic areas (the seat of our emotions, passions and drives). Working as a whole the ACC helps integrate thought with feeling as well as attention with motivation. The ventral ACC is extremely rich in serotonin transporters.

Although depression is a highly complex phenomenon with multiple causes, it appears that the ACC is involved. One study of depressed people using MRI found that depressed people had a smaller ACC than non-depressed volunteers. This study was published by Ramin S. Hastings of the New York Psychiatric Institute and colleagues in the March 2004 issue of Neuropharmacology.

Helen Mayberg. M.D. is a Board Certified neurologist who trained in neurology at  Columbia University and trained in nuclear medicine at Johns Hopkins. She has used PET scans to delineate brain activity in the neural circuits she believes play a role in causing depression. Dr. Mayberg has shown that the ventral ACC (also known as Broadmann’s Area 25) is hyperactive in depressed patients. She describes it as “a gate left open.” By that she means that negative, depressive emotions coming from the limbic area are allowed to flow freely across Area 25 in depressed patients and overwhelm the frontal lobes causing dark mood.

In February 2005 (just before she went to work at Emory University) Dr. Mayberg performed an experimental treatment on six seriously depressed patients at a clinic associated with Toronto University. She referred to these patients as being “terminally depressed,” since they had spent years in treatment with psychotherapy, anti-depressant medication and even electro-convulsive therapy, but had not gained any remission of their symptoms. Dr. Mayberg used a technique called DBS (deep brain stimulation) by inserting electrodes connected to a battery with adjustable current into Area 25 of their brains. All patients reported feeling better when the electric current pulsed into Area 25. Four of the six patients have achieved long term recovery from their depression by continuing to use DBS. Dr. Mayberg concluded that DBS had reduced and normalized the activity of their ventral ACC which effectively closed the gate between their negative emotions and their frontal lobes.

Dr. Mayberg continued her trials of DBS for treatment-refractory depressed patients. On February 19, 2009, the FDA approved the use of DBS for treatment of chronic, severe obsessive-compulsive disorder. Medtronic, Inc., the company which received the approval announced it would start a multi-center, randomized clinical trial of DBS for treatment-resistant depression.

If you’re a person who tried everything but failed to improve his depression without DBS, then wearing electrodes in your head and carrying around battery on your belt will be acceptable. On the other hand, what if you could significantly reduce your depressive symptoms through daily meditation? Wouldn’t that preferable?

There can be little doubt that forms of meditation devoted to increasing inner peace and tranquility or compassion and loving-kindness help relieve depression. One of the key factors in producing depression is high blood cortisol induced by chronic stress. Once you become depressed, the depressed state of mind keeps your cortisol level high because depressed people feel helpless, hopeless, and blameworthy, and they verbally attack themselves.

In September 1991 R. Sudsuang and colleagues in the Department of Physiology and Anatomy, Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand, published a paper in Physiology & Behavior showing that 52 males aged 20-25 who  meditated regularly had significantly lower blood cortisol and blood pressure then 30 males in the same age group who did not meditate.

Zen meditation has been associated with decreased sensitivity to emotional and physical pain. In February 2010 Joshua A. Grant and colleagues in the Department of Physiology at the Universite de Montreal published a paper in a special issue of the APA Journal Emotion exploring the relationship of Zen meditation, cortical thickness and pain sensitivity. The researchers recruited 17 Zen meditators and 18 non-meditators. They measured pain sensitivity by applying a heated plate to the calf of the participants and followed by measuring brain volume with structural MRI. They determined that the Zen meditators were significantly less sensitive to pain and that consequent to years of meditation they had substantially thicker gray matter in their dorsal ACC, parts of their hippocampus and their insula – all areas involved in pain regulation.

Richard Davidson, Ph.D. is a neuroscientist who has been meditating every day since 1974 (while pursuing his Ph.D. at Harvard University) and has been a personal friend of the Dalai Lama since 1992. He is known all over the world for his work on how meditation physically changes the structure and function of our brains along with our emotional lives – in particular how meditation makes use of the neuroplasticity of our brains to make us more empathic, compassionate, and loving human beings. Dr. Davidson runs the Lab for Affective Neuroscience at the University of Wisconsin where he has done many groundbreaking studies using MRI on meditating Buddhist monks.

In one well known paper in 2003 Dr. Davidson teamed up with Jon Kabat-Zinn to study the effect of eight weeks of meditation on non-meditators. As reported in Volume 65 of Psychosomatic Medicine, the eight weeks led to increased subjective feelings of wellbeing, increased brain activation of the left frontal cortex (which is associated with feelings of wellbeing) and increased immune function with increased resistance to the flu virus.

Dr. Davidson has studied the ACC. In the July 28, 2000 issue of Science Dr. Davidson and colleagues used functional brain scans to analyze the brains of 500 people with difficulty regulating emotion including 41 murders. They found that murders had little or no activity in the orbito-frontal cortex (OFC) and ACC with heightened activity in their amygdala (which sounds the fear alarm in response to potential threats). The OFC is supposed to constrain violent impulses, while the ACC mediates between the OFC and the amygdala and is supposed to help resolve decisions about how to respond to threat. These individuals became overwhelmed by the neural messages of threat/fear/defend from the amygdala, because their OFC and ACC were not functioning normally.

Based on the work of Dr. Mayberg and Dr. Davidson it appears that abnormalities in ACC function (hyperactivity or no activity) are associated with depression or violence. This makes sense since depression is a form of violence directed at the self. Further violence and depression are both mental states of great agitation, unhappiness and suffering associated with inability to regulate one’s emotions.

Meditation can thicken and strengthen your ACC, and help you regulate your emotions and decrease your sensitivity to emotional and physical pain. It can make you less reactive and more even-keeled. If you haven’t  tried it, start today. Begin exploring various forms of meditation taught in community and find one that works for you.

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